## Abstract ## Background and Objective Familial amyotrophic lateral sclerosis (FALS) is a neurodegenerative disease characterized by progressive loss of motor neurons and death. Mitochondrial dysfunction and oxidative stress play an important role in motor neuron loss in ALS. Light therapy (LT) h
Current status of thyrotropin-releasing hormone therapy in amyotrophic lateral sclerosis
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 277 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
โฆ Synopsis
Amyotrophic lateral sclerosis (ALS) and its variants are feared progressive neurological diseases of which the etiology and pathogenesis are unknown and for which therapy is unavailable. In 1983, Engel and associates 1 11 reported that infusion of thyrotropin-releasing hormone (TRH) improved strength and lessened spasticity in patients with ALS. Their report generated hope that, at long last, an effective treatment may exist. In this report we assess the current status of the evidence for using TRH in the management of patients with ALS.
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