๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Current status of the therapy of advanced renal carcinoma

โœ Scribed by William J. Hrushesky; Dr. Gerald P. Murphy

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
704 KB
Volume
9
Category
Article
ISSN
0022-4790

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โœฆ Synopsis

Abstract

A preclinical murine renal tumor model system is available for evaluation of the effectiveness of therapeutic agents. Clinical review reveals that objective response rates to hormonal agents reported since 1971 have been substantially lower than those reported prior to 1971. Many chemotherapeutic agents have not been adequately evaluated clinically or with the experimental model. Vinblastine to date may be the most active single agent with a 25% objective response rate. At the present time, it is uncertain whether combination chemotherapy or hormonal chemotherapy add to response rates obtained with single agents. There is some evidence that immunotherapy may be of some adjuvant benefit and, thus, may provide an additional avenue of investigation.

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