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Current Protocols in Pharmacology || In Vitro Enzymatic Assays of Protein Tyrosine Phosphatase 1B

✍ Scribed by Enna, S.J.; Williams, Michael; Ferkany, John W.; Kenakin, Terry; Porsolt, Roger D.; Sullivan, James P.

Book ID
121014930
Publisher
Wiley (John Wiley & Sons)
Year
2001
Tongue
English
Weight
243 KB
Volume
13
Category
Article
ISBN-13
9780471141754
ISSN
1934-8282

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An RNA Aptamer That Selectively Inhibits
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✍ Brent Townshend; Isabelle Aubry; Richard C. Marcellus; Kalle Gehring; Michel L. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 412 KB πŸ‘ 2 views

## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin