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Current prodrug strategies for improving oral absorption of nucleoside analogues

✍ Scribed by Zhang, Youxi; Gao, Yikun; Wen, Xiaojing; Ma, Haiying


Book ID
121992580
Publisher
Elsevier
Year
2014
Tongue
English
Weight
704 KB
Volume
9
Category
Article
ISSN
1818-0876

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Prodrugs of nucleoside analogues for imp
✍ Fujun Li; Hans Maag; Tom Alfredson πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 301 KB

Nucleoside analogues are widely used for the treatment of antiviral infections and anticancer chemotherapy. However, many nucleoside analogues suffer from poor oral bioavailability due to their high polarity and low intestinal permeability. In order to improve oral absorption of these polar drugs, p