Prodrugs of nucleoside analogues for imp
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Fujun Li; Hans Maag; Tom Alfredson
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Article
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2008
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John Wiley and Sons
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English
β 301 KB
Nucleoside analogues are widely used for the treatment of antiviral infections and anticancer chemotherapy. However, many nucleoside analogues suffer from poor oral bioavailability due to their high polarity and low intestinal permeability. In order to improve oral absorption of these polar drugs, p