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Current pharmacological treatments for nicotine dependence

✍ Scribed by Tony P George; Stephanie S O'Malley

Book ID: 116918364
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 244 KB
Volume: 25
Category: Article
ISSN: 0165-6147
DOI: 10.1016/j.tips.2003.11.003

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Like many psychostimulant drugs, nicotine elevates extracellular and synaptic dopamine (DA) concentrations in the nucleus accumbens (NAc). This elevation has been linked to its reinforcing properties. Dopaminergic transmission within the NAc is modulated by gamma-aminobutyric acid (GABA). Therefore,