Current issues in the management of acute promyelocytic leukemia
β Scribed by J. L. Slack; Michael E. Rusiniak
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 417 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0939-5555
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The chromosome breakpoints of the acute promyelocytic leukemia (APL)-specific 15;17 translocation have recently been isolated. They are localized on a previously unknown gene, PML, on chromosome 15 and in the gene that encodes the alpha retinoic acid receptor (RART) on 17. The translocation, which i
Acute Promyelocytic Leukemia (APL) is a distinct subtype of myeloid leukemia that in the USA alone affects more than 3,000 individuals every year. APL is characterized by three distinct and unique features: i) the accumulation in the bone marrow of tumor cells with promyelocytic features; ii) the in