Current Gene-Mapping Strategies in Experimental Models of Multiple Sclerosis
✍ Scribed by K. Becanovic; M. Jagodic; E. Wallström; T. Olsson
- Book ID
- 110749644
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 153 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0300-9475
No coin nor oath required. For personal study only.
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The destruction of central nervous system (CNS) myelin, the lipid-rich insulator surrounding axons in the mammalian brain and spinal cord, is the primary pathological finding in multiple sclerosis. Myelin loss can result in a significant clinical deficit, and was originally thought to be permanent,
## Abstract Cuprizone‐induced demyelination is a mouse model of multiple sclerosis (MS) as cuprizone‐fed mice exhibit neuroinflammation and demyelination in the brain. Upon removal of cuprizone from the diet, inflammation is resolved and reparative remyelination occurs. In an Affymetrix GeneChip an