## Abstract The past 25 years have seen a major expansion of knowledge concerning the cause of Parkinson's disease provided by an understanding of environmental and genetic factors that underlie the loss of nigral dopaminergic neurons. Based on the actions of toxins, postmortem investigations, and
Current concepts on the etiology of Parkinson's disease
β Scribed by Donald B. Calne
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 251 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
β¦ Synopsis
In recent years, attention has repeatedly been drawn to the links between aging of the nervous system and Parkinson's disease. Associations derive from (a) the high prevalence of Parkinson's disease in the elderly; (b) the clinical similarities between normal neurological aging and the features of Parkinson's disease; (c) comparisons between normal physiological, biochemical, and morphological aging of the brain and comparable changes in Parkinson's disease; (d) the long latency between exposure to certain environmental risk factors for parkinsonism, and the appearance of clinical features; and (e) the accelerated rate of progress of Parkinson's disease of late onset versus early onset.
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## Abstract Levodopa is the most effective symptomatic agent in the treatment of Parkinson's disease (PD) and the βgold standardβ against which new agents must be compared. However, there remain two areas of controversy: (1) whether levodopa is toxic, and (2) whether levodopa directly causes motor
## Abstract Companion letters have been published in __Movement__ Disorders: Current Controversies: Levodopa in the Treatment of Parkinson's Disease, by Sharma, Vassallo, and Ross and Reply: Levodopa in the Treatment of Parkinson's Disease, by Olanow, Agid, and Mizuno.