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Cure of Acanthamoeba cerebral abscess in a liver transplant patient

✍ Scribed by Konrad Tang-Tat Fung; Amar Paul Dhillon; James E. McLaughlin; Sebastian B. Lucas; Brian Davidson; Keith Rolles; David Patch; Andrew K. Burroughs


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
344 KB
Volume
14
Category
Article
ISSN
1527-6465

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✦ Synopsis


Acanthamoeba-related cerebral abscess and encephalitis are rare but usually fatal, being caused by free-living amoebic infections usually occurring in immunocompromised patients. In patients receiving transplants, a literature review showed that the infection is universally fatal. The diagnosis is often missed despite appropriate investigations including lumbar puncture, computerized tomography, and brain biopsy. We present the first reported liver transplant patient with Acanthamoeba cerebral abscess. The diagnosis was made in brain tissue removed at decompressive frontal lobectomy. He was successfully treated with a 3-month course of co-trimoxazole and rifampicin. There was no recurrence of the disease after 11 years of follow-up.


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