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Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice

✍ Scribed by Yu-Tang Tung; Hsiao-Ling Chen; Cheng-Wei Lai; Chih-Jie Shen; Yi-Wen Lai; Chuan-Mu Chen

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
389 KB
Volume
55
Category
Article
ISSN
1613-4125

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✦ Synopsis

Abstract

Scope: We investigated the inhibition of pulmonary tumor formation through treatment with curcumin in transgenic mice.

Methods and results: In this study, a strain of transgenic mice carrying human vascular endothelial growth factor A~165~ (hVEGF‐A~165~) gene to induce pulmonary tumor was used as an in vivo cancer therapy model. We found that curcumin significantly reduced hVEGF‐A~165~ overexpression to normal, specifically in Clara cells of the lungs of transgenic mice, and suppressed the formation of tumors. In addition, we demonstrated a relationship between curcumin treatment and the expression of VEGF, EGFR, ERK2, and Cyclin A at the transcriptional and translational levels. We also noticed a reduction of Cyclin A and Cyclin B after curcumin treatment that had an effect on the cell cycle. Curcumin‐induced inhibition of Cyclin A and Cyclin B likely results in decreased progression through S and G2/M phases. These results demonstrated that the expression of proteins involved in the S to M phase transition in transgenic mice is suppressed by curcumin.

Conclusion: A Data suggest that a blockade of the cell cycle may be a critical mechanism for the observed effects on vasculogenesis and angiogenesis following treatment with curcumin.

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