Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated receptor-γ function

Activation of calcium/calmodulin-depende

Activation of calcium/calmodulin-dependent protein kinase IV and peroxisome proliferator-activated receptor γ coactivator-1α signaling pathway protects against neuronal injury and promotes mitochondrial biogenesis in the hippocampal CA1 subfield after transient global ischemia

✍ Shang-Der Chen; Tsu-Kung Lin; Jui-Wei Lin; Ding-I Yang; Su-Ying Lee; Fu-Zen Shaw 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 481 KB 👁 1 views

## Abstract Delayed neuronal cell death occurs in the vulnerable CA1 subfield of the hippocampus after transient global ischemia (TGI). We demonstrated previously, based on an experimental model of TGI, that the significantly increased content of oxidized proteins in hippocampal CA1 neuron was obse