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Curcumin p38-dependently enhances the anticancer activity of valproic acid in human leukemia cells

✍ Scribed by Jie Chen; Guiying Wang; Libing Wang; Jiuhong Kang; Jianmin Wang


Book ID
113592335
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
643 KB
Volume
41
Category
Article
ISSN
0928-0987

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The mechanism of the induction of apoptosis by arsenic trioxide (As 2 O 3 ), which was demonstrated recently to be an effective inducer of apoptosis in patients with leukemia, was examined in detail in human leukemia U937 cells. Upon treatment of U937 cells with 50 M of As 2 O 3 , complete inactivat