## Abstract Curcumin (diferuloylmethane), a polyphenol natural product of the plant __Curcuma longa__, is undergoing early clinical trials as a novel anticancer agent. However, the anticancer mechanism of curcumin remains to be elucidated. Here we show that curcumin inhibited growth of rhabdomyosar
Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
β Scribed by Maha H. Elamin; Zakia Shinwari; Siti-Faujiah Hendrayani; Hindi Al-Hindi; Essam Al-Shail; Yasser khafaga; Amani Al-kofide; Abdelilah Aboussekhra
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 451 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0899-1987
- DOI
- 10.1002/mc.20604
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Dauricine, a bioactive component of Asiatic Moonseed Rhizome, has been widely used to treat a large number of inflammatory diseases in traditional Chinese medicine. In our study, we demonstrated that dauricine inhibited colon cancer cell proliferation and invasion, and induced apoptosis
## Abstract Sonic hedgehog (SHH) is essential for the development of the cochlear duct that harbors the organ of Corti. However, little is known about the molecular signaling pathway through which SHH promotes the development of the organ of Corti, especially cochlear sensory epithelial cells. In t
## Abstract ## Background Activation of the hedgehog pathway may contribute to carcinogenesis. This study characterizes the expression pattern in squamous cell carcinoma of the skin and the head and neck. ## Methods Tissue microarrays were constructed with samples of squamous cell carcinoma of t
## Abstract We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the root and stem bark of the oriental herb __Magnolia officinalis__, induced apoptotic cell death in a doseβ and timeβdependent manner. A sustained inhibition of the major su