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Cumulative influence of elastin peptides and plasminogen on matrix metalloproteinase activation and type

✍ Scribed by Eric Huet; Bertrand Brassart; Jean-Hubert Cauchard; Laurent Debelle; Philippe Birembaut; Jean Wallach; Herve Emonard; Myriam Polette; William Hornebeck

Book ID: 110329862
Publisher: Springer
Year: 2002
Tongue: English
Weight: 250 KB
Volume: 19
Category: Article
ISSN: 0262-0898
DOI: 10.1023/a:1014547324918

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In the normal heart, cardiomyocytes are surrounded by extracellular matrix (ECM) and latent matrix metalloproteinases (MMPs), which are produced primarily by cardiac fibroblasts. An activator of latent MMPs might be induced by ischemic conditions or pressure-induced stretching. To test the hypothesi