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Cumulative inactivation and the pore domain in the Kv1 channels

โœ Scribed by Yoriko Shimizu; Tai Kubo; Yasuo Furukawa


Book ID
106109056
Publisher
Springer
Year
2002
Tongue
English
Weight
134 KB
Volume
443
Category
Article
ISSN
0031-6768

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## Abstract Using the whole-cell patch-clamp technique, we investigated the influence of extracellular pH and zinc ions (Zn2+) on the steady-state inactivation of Kv1.3 channels expressed in human lymphocytes. The obtained data showed that lowering the extracellular pH from 7.35 to 6.8 shifted the