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CuI-Catalyzed Alkyne—Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

✍ Scribed by Victoria D. Bock; Henk Hiemstra; Jan H. van Maarseveen


Book ID
101983471
Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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CuI-Catalyzed Alkyne–Azide “Click” Cyclo
✍ Victoria D. Bock; Henk Hiemstra; Jan H. van Maarseveen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 414 KB

## Abstract Cu^I^‐catalyzed alkyne–azide cycloaddition provides 1,4‐disubstituted 1,2,3‐triazoles with such efficiency and scope that the transformation has been described as “click” chemistry. An overview of the mechanism of this remarkable reaction is presented as a means to explain the myriad of