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Cu2+-catalyzed peptide bond formation in the reaction of 5-deoxypyridoxal and α-phenyl-α-aminomalonic acid

✍ Scribed by Max Blum; Wells C. Cunningham; John W. Thanassi


Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
663 KB
Volume
5
Category
Article
ISSN
0045-2068

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✍ Metwally, Saoud A. M. ;Aly, Moustafa F. ;Abd-Alla, Mohamed A. ;Atta, Ferial M. ; 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 255 KB 👁 1 views

## Abstract 4‐(Dicyanomethylene)‐3‐methyl‐1‐phenyl‐2‐pyrazoline‐5‐one (1) readily reacts with α‐amino acids and their esters by Michael addition and subsequent elimination of HCN to the adducts 2a–k. One of these, 2i (obtained from methyl glycinate), adds stereoselectively to __N__‐phenylmaleimide