CTLA4 exon 1 polymorphism, rheumatoid arthritis and autoimmune endocrinopathy
β Scribed by Steven Young-Min; Bijay Vaidya
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 110 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0770-3198
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## Abstract ## Objective Recent advances have led to novel identification of genetic polymorphisms that are associated with susceptibility to rheumatoid arthritis (RA). Currently, 5 loci (__HLA__, __PTPN22__, __TRAF1__/__C5__, __TNFAIP3__, and __STAT4__) have been consistently reported, whereas ot
Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1\*0301 and DRB1\*0401. The gene encoding cytotoxic T-lymphocyte antigen-4 (CTLA-4) on chromosome 2q33 may also influence autoimmuni