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CTLA-4Ig blocks the development and progression of citrullinated fibrinogen–induced arthritis in DR4-transgenic mice

✍ Scribed by David Yue; William Brintnell; Lisa A. Mannik; Darah A. Christie; S. M. Mansour Haeryfar; Joaquín Madrenas; Subrata Chakrabarti; David A. Bell; Ewa Cairns

Book ID
102753220
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
887 KB
Volume
62
Category
Article
ISSN
0004-3591

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✍ Tsvetelina Batsalova; Balik Dzhambazov; Patrick Merky; Alexandra Bäcklund; Johan 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB 👁 1 views

## Abstract ## Objective To establish a new animal model in DRB1\*0401 (DR4)–transgenic mice in which T cell tolerance to self type II collagen (CII) can be broken and allow for the development of autoimmune arthritis, to investigate the role of posttranslational modifications of the CII^259–273^