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CTLA-4 blockade and the renaissance of cancer immunotherapy

✍ Scribed by Mocellin, Simone; Nitti, Donato

Book ID: 120451438
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 698 KB
Volume: 1836
Category: Article
ISSN: 0304-419X
DOI: 10.1016/j.bbcan.2013.05.003

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Cytotoxic T lymphocyte antigen-4 has become recognized as one of the key negative regulators of adaptive immune responses, having a central role in the maintenance of peripheral tolerance and in shaping the repertoire of emergent T cell responses. Concurrent recognition of the potential importance o