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CTEN Regulates Clonogenic Proliferation of Human Lung Adenocarcinoma Cells and is Regulated by Extracellular Regulated Kinase (ERK)

✍ Scribed by Bennett, Daine T.; Venardos, Neil M.; Foley, Lisa S.; Rove, Jessica Y.; Meng, Xianzhong; Reece, Thomas B.; Fullerton, David A.; Weyant, Michael J.


Book ID
127388200
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
61 KB
Volume
219
Category
Article
ISSN
1072-7515

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The AU565 breast carcinoma cell line was used to determine the role of the extracellular-regulated kinase (ERK) pathway in mediating Heregulin␀1 (HRG␀1)-induced mammary cell differentiation. ERK activation remained elevated for 2 h following high doses of HRG which induce differentiation. In contras