CsOH-promoted chemoselective mono-N-alkylation of diamines and polyamines

✍ Scribed by Ralph N Salvatore; Shaun E Schmidt; Seung Il Shin; Advait S Nagle; Jay H Worrell; Kyung Woon Jung

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 60 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01747-0

✦ Synopsis

Selective N-alkylation of diamines and polyamines was carried out using cesium hydroxide, 4 A , molecular sieves, and DMF. This protocol was highly chemoselective, favoring mono-N-alkylation over overalkylations.