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CSF drug levels for children with acute lymphoblastic leukemia treated by 5 g/m2 methotrexate

✍ Scribed by Milano, G.; Thyss, A.; Serre Debeauvais, F.; Laureys, G.; Benoit, Y.; Deville, A.; Dutour, C.; Robert, A.; Otten, J.; Behar, C.; Frappaz, D.

Book ID
121931293
Publisher
Elsevier Science
Year
1990
Weight
536 KB
Volume
26
Category
Article
ISSN
0277-5379

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Comparative study on the pharmacokinetic
Comparative study on the pharmacokinetics of 7-hydroxy-methotrexate after administration of methotrexate in the dose range of 0.5-33.6 g/m2 to children with acute lymphoblastic leukemia
✍ Borsi, Joseph D. ;Sagen, Erling ;Romslo, Inge ;Moe, Peter J. πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 694 KB

## Abstract Concentrations of __7__‐hydroxy‐methotrexate (__7__‐OH‐MTX) were determined in serum samples obtained after 266 infusions of methotrexate administered to 58 children with acute lymphoblastic leukemia. The dose of methotrexate (MTX) was in the range of 0.5‐33.6 g/m^2^. Pharmacokinetic pa