𝔖 Bobbio Scriptorium
✦   LIBER   ✦

CSF Aβ42 and tau in Parkinson's disease with cognitive impairment

✍ Scribed by Thomas J. Montine; Min Shi; Joseph F. Quinn; Elaine R. Peskind; Suzanne Craft; Carmen Ginghina; Kathryn A. Chung; Hojoong Kim; Douglas R. Galasko; Joseph Jankovic; Cyrus P. Zabetian; James B. Leverenz; Jing Zhang

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
645 KB
Volume
25
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We tested the hypothesis that the CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals with Parkinson's disease and Dementia (PD‐D) or with PD and Cognitive Impairment, Not Dementia (PD‐CIND). We quantified CSF Aβ~42~, total tau (T‐tau), and phospho‐tau (P181‐tau) using commercially available kits. Samples were from 345 individuals in seven groups (n): Controls ≤50 years (35), Controls >50 years (115), amnestic Mild Cognitive Impairment (aMCI) (24), AD (49), PD (49), PD‐CIND (62), and PD‐D (11). We observed expected changes in AD or aMCI compared with age‐matched or younger controls. CSF Aβ~42~ was reduced in PD‐CIND (P < 0.05) and PD‐D (P < 0.01), whereas average CSF T‐tau and P181‐tau were unchanged or decreased. One‐third of PD‐CIND and one‐half of PD‐D patients had the biomarker signature of AD. Abnormal metabolism of Aβ~42~ may be a common feature of PD‐CIND and PD‐D. © 2010 Movement Disorder Society

📜 SIMILAR VOLUMES

MRI and cognitive impairment in Parkinso
MRI and cognitive impairment in Parkinson's disease
✍ Naroa Ibarretxe-Bilbao; Eduardo Tolosa; Carme Junque; Maria-Jose Marti 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 73 KB 👁 1 views

## Abstract Patients with Parkinson's disease (PD) may present impairment in cognitive functions even at early stages of the disease. When compared with the general population, their risk of dementia is five to six times higher. Recent investigations using structural MRI have shown that dementia in

Cognitive impairment and dementia in Par
Cognitive impairment and dementia in Parkinson's disease
✍ Karen Marder 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 85 KB 👁 1 views

## Abstract Over the last decade, the importance of cognitive impairment and dementia in Parkinson's disease (PDD) has been increasingly recognized. Investigators have proposed criteria for PD dementia, and mild cognitive impairment. Risk profiles associated with the development of dementia based o

Cognitive impairment in nondemented Park
Cognitive impairment in nondemented Parkinson's disease
✍ Paolo Barone; Dag Aarsland; David Burn; Murat Emre; Jaime Kulisevsky; Daniel Wei 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB 👁 1 views

## Abstract A substantial percentage of patients with newly diagnosed Parkinson's disease without dementia are reported to be affected by cognitive impairment (CI). In practice, however, CI is underrecognized, as the signs may not be apparent in early‐stage disease and many routine assessment tools