Crystals of a 1 : 1 complex between human interleukin-4 and the extracellular domain of its receptor α chain
✍ Scribed by Thorsten Hage; Peter Reinemer; Walter Sebald
- Book ID
- 114429542
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 229 KB
- Volume
- 258
- Category
- Article
- ISSN
- 1432-1327
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X-ray diffraction quality crystals have been obtained from a complex between interferon y and the extracellular domain of its high-affinity cell surface receptor. The crystals were obtained from interferon ylinterferon y receptor complexes purified by size exclusion chromatography. Diffraction quali
## Abstract Human interleukin 4 (IL 4) acts on various hematopoietic cell types through interaction with a specific cell surface receptor (IL 4R), whose cDNA has been cloned. We have produced a cDNA encoding a soluble form of the extracellular domain of the human IL 4R (sIL 4R) and describe here th