Human leukocyte elastase (HLE) is a serine protease that contributes to tissue destruction in various disease states-for example, in emphysema. FR901277 is a natural product isolated from the culture filtrate of Streptomyces resistomicificus and is a potent inhibitor of both HLE and porcine pancreat
✦ LIBER ✦
Crystallographie study of a β-lactam inhibitor complex with elastase at 1.84 Å resolution
✍ Scribed by Navia, Manuel A.; Springer, James P.; Lin, Tsau-Yen; Williams, Hollis R.; Firestone, Raymond A.; Pisano, Judith M.; Doherty, James B.; Finke, Paul E.; Hoogsteen, Karst
- Book ID
- 109749343
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 420 KB
- Volume
- 327
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/327079a0
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