Crystallographic portrayal of different conformational states of a Lys49 phospholipase A2 homologue: Insights into structural determinants for myotoxicity and dimeric configuration

Crystallographic and spectroscopic chara

Crystallographic and spectroscopic characterization of a molecular hinge: Conformational changes in bothropstoxin I, a dimeric Lys49-phospholipase A2 homologue

✍ M.T. da Silva Giotto; R.C. Garratt; G. Oliva; Y.P. Mascarenhas; J.R. Giglio; A.C 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 458 KB

Bothropstoxin I (BthTX-I) from the venom of Bothrops jararacussu is a myotoxic phospholipase A2 (PLA2) homologue which, although catalytically inactive due to an Asp49=Lys substitution, disrupts the integrity of lipid membranes by a Ca 2؉ -independent mechanism. The crystal structures of two dimeric