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Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase

✍ Scribed by Tarmo Ploom; Beat Thöny; Jeongbin Yim; Soojin Lee; Herbert Nar; Walter Leimbacher; John Richardson; Robert Huber; Günter Auerbach


Book ID
115629095
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
373 KB
Volume
286
Category
Article
ISSN
0022-2836

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Hyperphenylalaninemia (HPA) may be caused by deficiency of phenylalanine hydroxylase or tetrahydrobiopterin (BH4), the essential cofactor for the aromatic amino acid hydroxylases. 6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency is a major cause of BH4 deficient HPA. In this study, seven singl