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Crystallization studies of cAMP-dependent protein kinase

✍ Scribed by Sowadski, Janusz M.; Xuong, Nguyen huu; Anderson, Daniel; Taylor, Susan S.


Book ID
123338780
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
589 KB
Volume
182
Category
Article
ISSN
0022-2836

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The CAMP-dependent protein kinase (cAK) from Diciyosteliurn discoideurn is an enzyme composed of one catalytic and one regulatory subunit. Upon binding of CAMP, the holoenzyme dissociates to liberate free active catalytic subunits. The cAK is developmentally regulated, ranging from very little activ