Crystallization of pure anhydrous polymorphs of carbamazepine by solution enhanced dispersion with supercritical fluids (SEDS™)
✍ Scribed by Anthony D. Edwards; Boris Yu Shekunov; Andreas Kordikowski; Robert T. Forbes; Peter York
- Book ID
- 102398040
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 281 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0022-3549
- DOI
- 10.1002/jps.1065
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✦ Synopsis
Pure anhydrous polymorphs of carbamazepine were prepared by solutionenhanced dispersion with supercritical ¯uids (SEDS TM ). Crystallization of the polymorphs was studied. Mechanisms are proposed that consider the thermodynamics of carbamazepine, supersaturation in the SEDS TM process, and the binary phase equilibria of organic solvents and the carbon dioxide antisolvent. a-Carbamazepine was crystallized at high supersaturations and low temperatures, b-carbamazepine crystallized from a methanol±carbon dioxide phase split, and g-carbamazepine crystallized via nucleation at high temperatures and low supersaturation.