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Crystallization of O6-methylguanine-DNA methyltransferase from Escherichia coli

✍ Scribed by Moody, Peter C.E.; Demple, Bruce


Book ID
122720448
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
149 KB
Volume
200
Category
Article
ISSN
0022-2836

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Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove