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Crystallization of Inhibitor Complexes of an N-Terminal 24 kDa Fragment of the DNA Gyrase B Protein

โœ Scribed by Richard J. Lewis; Onkar M.P. Singh; Clare V. Smith; Anthony Maxwell; Tadeusz Skarzynski; Alan J. Wonacott; Dale B. Wigley


Book ID
115626753
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
147 KB
Volume
241
Category
Article
ISSN
0022-2836

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Coumarin antibiotics, such as clorobiocin, novobiocin, and coumermycin A1, inhibit the supercoiling activity of gyrase by binding to the gyrase B (GyrB) subunit. Previous crystallographic studies of a 24-kDa Nterminal domain of GyrB from E. coli complexed with novobiocin and a cyclothialidine analog