Crystallization-induced asymmetric trans
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Yao-Jun Shi; Kenneth M. Wells; Philip J. Pye; Woo-Baeg Choi; Hywyn R.O. Churchil
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Article
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1999
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Elsevier Science
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French
β 539 KB
A highly convergent, asymmetric synthesis of L-768,673, an Iks Class III antiarrythmic drug candidate, is described. Synthesis of the racemic 1-trifluoroethyl-3-amino-5-phenyl benzodiazepinone [(~-amine] was achieved by Ru-catalyzed hydrogenation of the corresponding oxime that was derived from comm