Crystallization and stabilization of MB-1, a de novo designed protein for optimized feeding technology

Structural cassette mutagenesis in a de

Structural cassette mutagenesis in a de novo designed protein: Proof of a novel concept for examining protein folding and stability

✍ Stanley C. Kwok; Brian Tripet; Jeff H. Man; Mundeep S. Chana; Pierre Lavigne; Co 📂 Article 📅 1998 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 586 KB

The solution to the protein folding problem lies in defining the relative energetic contributions of short-range and long-range interactions. In other words, the tendency of a stretch of amino acids to adopt a final secondary structural fold is context dependent. Our approach to this problem is to a