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Crystallization and preliminary crystallographic studies of the recombinant antitumour lectin from the edible mushroom Agrocybe aegerita

✍ Scribed by Na Yang; Xin Tong; Ye Xiang; Ying Zhang; Hui Sun; Da-Cheng Wang

Book ID
104003439
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
154 KB
Volume
1751
Category
Article
ISSN
1570-9639

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✦ Synopsis

The antitumour lectin from Agrocybe aegerita, named AAL, shows strong inhibition effects on human and mouse tumour cells via apoptosis induction activity. Recombinant AAL (rAAL) has been expressed and purified. Both rAAL and rAAL -lactose complex have been crystallized and their X-ray diffraction data were collected to resolutions of 1.9 A ˚and 1.6 A ˚, respectively. Both crystals belong to space group

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