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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

โœ Scribed by Bandaranayake, Rajintha M; Ungureanu, Daniela; Shan, Yibing; Shaw, David E; Silvennoinen, Olli; Hubbard, Stevan R

Book ID
120039313
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
961 KB
Volume
19
Category
Article
ISSN
1545-9993

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JAK2V617F is a common mutation in chronic myeloproliferative diseases (CMPDs). We have developed a system utilizing JAK2V617Fspecific guanine quenching probe (QP-system) to detect JAK2V617F. With QP-system, results can be obtained from 100 l of blood within 90 min. We compared QP-system with direct