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Crystal Structures of Complexes of a Peptidic Inhibitor with Wild-Type and Two Mutant HIV-1 Proteases †,‡

✍ Scribed by Hong, Lin; Treharne, Annemarie; Hartsuck, Jean Ann; Foundling, Steve; Tang, Jordan


Book ID
127169272
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
454 KB
Volume
35
Category
Article
ISSN
0006-2960

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Three forms of feline immunodeficiency virus protease (FIV PR), the wild type (wt) and two single point mutants, V59I and Q99V, as well as human immunodeficiency virus type 1 protease (HIV-1 PR), were cocrystallized with the C2symmetric inhibitor, TL-3. The mutants of FIV PR were designed to replace