Crystal Structures of a Second G Protein-Coupled Receptor: Triumphs and Implications
✍ Scribed by Abby L. Parrill
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 235 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1860-7179
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## Abstract The α‐factor receptor(Ste2p) is required for the sexual conjugation of the yeast Saccharomyces cerevisiae. Ste2p belongs to the G protein‐coupled receptor (GPCR) family sharing a common heptahelical transmembrane structure. Biological synthesis of regions of Ste2p fused to a leader prot
Peptides representing both loop and the sixth transmembrane regions of the ␣-factor receptor of Saccharomyces cerevisiae were synthesized by solid-phase procedures and purified to near homogeneity. CD, nmr, and modeling analysis indicated that in aqueous media the first extracellular loop peptide E1