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Crystal structure reveals basis for the inhibitor resistance of human brain trypsin

✍ Scribed by Gergely Katona; Gunnar I Berglund; Janos Hajdu; László Gráf; László Szilágyi


Book ID
115631597
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
500 KB
Volume
315
Category
Article
ISSN
0022-2836

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## Abstract β‐Lactams are the most commonly prescribed class of antibiotics and have had an enormous impact on human health. Thus, it is disquieting that an enzyme called New Delhi metallo‐β‐lactamase‐1 (NDM‐1) can confer Enterobacteriaceae with nearly complete resistance to all β‐lactam antibiotic