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Crystal structure ofRattus norvegicusVisfatin/PBEF/Nampt in complex with an FK866-based inhibitor

✍ Scribed by Gil Bu Kang; Man-Ho Bae; Mun-Kyoung Kim; Isak Im; Yong-Chul Kim; Soo Hyun Eom


Book ID
106262945
Publisher
Korean Society for Molecular and Cellular Biology
Year
2009
Tongue
English
Weight
393 KB
Volume
27
Category
Article
ISSN
1016-8478

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Crystal structure of a soluble form of h
✍ CΓ©line Schalk-Hihi; Carsten Schubert; Richard Alexander; Shariff Bayoumy; Jose C πŸ“‚ Article πŸ“… 2011 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 724 KB

## Abstract A high‐resolution structure of a ligand‐bound, soluble form of human monoglyceride lipase (MGL) is presented. The structure highlights a novel conformation of the regulatory lid‐domain present in the lipase family as well as the binding mode of a pharmaceutically relevant reversible inh