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Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation

✍ Scribed by Guillet, Valérie; Knibiehler, Martine; Gregory-Pauron, Lynn; Remy, Marie-Hélène; Chemin, Cécile; Raynaud-Messina, Brigitte; Bon, Cécile; Kollman, Justin M; Agard, David A; Merdes, Andreas; Mourey, Lionel


Book ID
118220275
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
950 KB
Volume
18
Category
Article
ISSN
1545-9993

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The crystal structure of ribonuclease A
✍ Nicolas Doucet; Thusitha B. Jayasundera; Miljan Simonović; J. Patrick Loria 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 853 KB

## Abstract Thymidine‐3′‐monophosphate (3′‐TMP) is a competitive inhibitor analogue of the 3′‐CMP and 3′‐UMP natural product inhibitors of bovine pancreatic ribonuclease A (RNase A). Isothermal titration calorimetry experiments show that 3′‐TMP binds the enzyme with a dissociation constant (__K__~d