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Crystal Structure of the Pregnane X Receptor-Estradiol Complex Provides Insights into Endobiotic Recognition

✍ Scribed by Xue, Yu; Moore, Linda B.; Orans, Jillian; Peng, Li; Bencharit, Sompop; Kliewer, Steven A.; Redinbo, Matthew R.


Book ID
127394963
Publisher
Endocrine Society
Year
2007
Tongue
English
Weight
827 KB
Volume
21
Category
Article
ISSN
0888-8809

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## Abstract Thymidine‐3′‐monophosphate (3′‐TMP) is a competitive inhibitor analogue of the 3′‐CMP and 3′‐UMP natural product inhibitors of bovine pancreatic ribonuclease A (RNase A). Isothermal titration calorimetry experiments show that 3′‐TMP binds the enzyme with a dissociation constant (__K__~d