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Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit ∥

✍ Scribed by Ippolito, Joseph A.; Kanyo, Zoltan F.; Wang, Deping; Franceschi, Francois J.; Moore, Peter B.; Steitz, Thomas A.; Duffy, Erin M.


Book ID
120060043
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
732 KB
Volume
51
Category
Article
ISSN
0022-2623

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Binding of erythromycin to the 50S ribos
✍ Saltzman, Larry ;Apirion, David 📂 Article 📅 1976 🏛 Springer 🌐 English ⚖ 644 KB

Expression of resistance to erythromycin in Escherichia coli, caused by an altered L4 protein in the 50S ribosomal subunit, can be masked when two additional ribosomal mutations affecting the 30S proteins S5 and S12 are introduced into the strain (Saltzman, Brown, and Apriion, 1974). Ribosomes from