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Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone

✍ Scribed by Amick, Joseph; Schlanger, Simon E.; Wachnowsky, Christine; Moseng, Mitchell A.; Emerson, Corey C.; Dare, Michelle; Luo, Wen-I; Ithychanda, Sujay S.; Nix, Jay C.; Cowan, J. A.; Page, Richard C.; Misra, Saurav


Book ID
126078672
Publisher
Cold Spring Harbor Laboratory Press
Year
2014
Tongue
English
Weight
469 KB
Volume
23
Category
Article
ISSN
0961-8368

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## Abstract The major inducible 70 kDa heat shock protein (hsp70) binds the measles virus (MeV) nucleocapsid with high affinity in an ATP‐dependent manner, stimulating viral transcription and genome replication, and profoundly influencing virulence in mouse models of brain infection. Binding is med