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Crystal structure of the mismatch-specific thymine glycosylase domain of human methyl-CpG-binding protein MBD4

✍ Scribed by Wei Zhang; Zhonglai Liu; Lissete Crombet; Maria F. Amaya; Yanli Liu; Xiaoru Zhang; Wenhua Kuang; Pengtao Ma; Liping Niu; Chao Qi


Book ID
118426402
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
787 KB
Volume
412
Category
Article
ISSN
0006-291X

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The human DNA repair protein MED1 (also known as MBD4) was isolated as an interactor of the mismatch repair protein MLH1 in a yeast two-hybrid screening. MED1 has a tripartite structure with an N-terminal 5-methylcytosine binding domain (MBD), a central region, and a C-terminal catalytic domain with