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Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

✍ Scribed by Morgan Huse; Ye-Guang Chen; Joan Massagué; John Kuriyan


Book ID
117267483
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
775 KB
Volume
96
Category
Article
ISSN
0092-8674

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Transforming growth factor-beta (TGF-beta) signaling is initiated following heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Both receptors are required for TGF-beta responsiveness. In the present study, we characterized the actions of TGF-b