Crystal structure of the bifunctional N-acetylglucosamine 1-phosphate uridyltransferase from Escherichia coli: a paradigm for the related pyrophosphorylase superfamily

Self-association studies of the bifuncti

Self-association studies of the bifunctional N-acetylglucosamine-1-phosphate uridyltransferase from Escherichia coli

✍ Jean-François Trempe; Solomon Shenker; Guennadi Kozlov; Kalle Gehring 📂 Article 📅 2011 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 576 KB

## Abstract The __N__‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU) is a key bifunctional enzyme in the biosynthesis of UDP‐GlcNAc, a precursor in the synthesis of cell wall peptidoglycan. Crystal structures of the enzyme from different bacterial strains showed that the polypeptide forms a