Crystal structure of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli
β Scribed by Igor A Shumilin; Robert H Kretsinger; Ronald H Bauerle
- Book ID
- 114329741
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 402 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0969-2126
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## Abstract In __Escherichia coli__, the phenylalanineβsensitive 3βdeoxyβDβarabinoβheptulosonateβ7βphosphate synthase (DAHPS) AroG catalyzes the first committed step in the biosynthesis of aromatic compounds. To investigate the feedback inhibition site of AroG, mutated enzymes prepared with sequenc
The phenylalanine-regulated isozyme of 3-deoxy-D-arabino-heptulosonate-7phosphate synthase (DAHPS) from Escherichia coli, its binary complexes with either substrate, phosphoenolpyruvate (PEP), or feedback inhibitor, Phe, and its ternary complexes with either PEP or Phe plus metal cofactor (either Mn