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Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

✍ Scribed by Joseph Schlessinger; Alexander N. Plotnikov; Omar A. Ibrahimi; Anna V. Eliseenkova; Brian K. Yeh; Avner Yayon; Robert J. Linhardt; Moosa Mohammadi


Book ID
117735963
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
406 KB
Volume
6
Category
Article
ISSN
1097-2765

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## Abstract Variations in sulfation of heparan sulfate (HS) affect interaction with FGF, FGFR, and FGF–HS–FGFR signaling complexes. Whether structurally distinct HS motifs are at play is unclear. Here we used stabilized recombinant FGF7 as a bioaffinity matrix to purify size‐defined heparin oligosa