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Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand

✍ Scribed by Aitziber L. Cortajarena; Jimin Wang; Lynne Regan

Book ID: 111313402
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 1019 KB
Volume: 277
Category: Article
ISSN: 1432-1327
DOI: 10.1111/j.1742-4658.2009.07549.x

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## Abstract Thymidine‐3′‐monophosphate (3′‐TMP) is a competitive inhibitor analogue of the 3′‐CMP and 3′‐UMP natural product inhibitors of bovine pancreatic ribonuclease A (RNase A). Isothermal titration calorimetry experiments show that 3′‐TMP binds the enzyme with a dissociation constant (__K__~d